Neuroleptic malignant syndrome (NMS), a serious condition that can lead to death.Tell your healthcare provider if you are taking LYBALVI before a medical procedure or surgery. feel faint, very dizzy, confused, or have unusual symptoms.have slow, shallow breathing (little chest movement with breathing).become very drowsy with slowed breathing.You or someone close to you should get emergency medical help right away if you: It is important that you tell your family and the people closest to you of this increased sensitivity to opioids and the risk of overdose. If you have used opioid street drugs or opioid-containing medicines in the past, using opioids in amounts that you used before treatment with LYBALVI can lead to overdose or death. You may be more sensitive to the effects of opioids. After you take LYBALVI, its blocking effect slowly decreases and completely goes away over time.This can lead to serious injury, coma, or death. Do not take large amounts of opioids to try to overcome the opioid-blocking effects of LYBALVI. LYBALVI blocks the effects of opioids, such as heroin, methadone, or opioid pain medicines. One of the medicines in LYBALVI (samidorphan) can increase your chance of having an opioid overdose that can cause death if you take opioids during treatment or within 5 days after stopping treatment with LYBALVI. You should not start taking opioids for at least 5 days after you stop treatment with LYBALVI.
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